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Our lab is interested in the organization of active zones in its relation to synaptic transmission regulation. We investigate the dynamics of quanta release and replenishment in a mature synapse, the NMJ, and the spatial localization of active release sites as a function of synaptic activity. We are also interested in the involvement of synapses in neurological diseases, such as in Spinal Muscular Atrophy. For the study of synaptic function and dysfunction we combine molecular, electrophysiological and optical tools and use genetic mouse models.

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Movie Lucia Tabares 46922
Laboratory Lucia Tabares 132547
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